Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. a. Suppose that all three of these libraries are sufficiently large

Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. a. Suppose that all three of these libraries are sufficiently large so as to represent all of the different human nucleotide sequences that the library could possibly include. Which of these libraries would then correspond to the largest fraction of the total human genome? b. Would you expect any of these libraries not to overlap the others at all in terms of the sequences it contains? Explain. c. How do these three libraries differ in terms of the starting material for constructing the clones in the library? d. Why would you need to sequence many clones from many cDNA libraries to annotate a genome?

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